Idiopathic thrombocytopenic purpura nursing care management. As usual, situations in real life are often more complicated than in guidelines. Hamed 218 diagnosis and management of thrombotic thrombocytopenic purpura page 3 of 6 9 re s e pv. Jan 03, 20 thrombocytopenia, defined as a platelet count 26 000 women suggest that its prevalence at the end of pregnancy is between 6. Idiopathic thrombocytopenic purpura itp is a disease that commonly affects women of reproductive age and is associated with maternal and fetal complications. If a woman with itp becomes pregnant, her platelet count may drop in the third. How i treat thrombocytopenia in pregnancy blood american. Pdf immune idiopathic thrombocytopenic purpura diagnosed in. A diagnosis of the autoimmune disease itp may change many things about your. Review thrombocytopenia in pregnancy rcog elearning.
It causes a characteristic red or purple bruiselike rash and an increased tendency to bleed. Among 446 pregnancies in women with itp, 346 resulted in live births. Wegnelius and others published immune thrombocytopenic purpura itp and pregnancy a prospective national. Thrombocytopenia low platelet count symptoms and causes. No consistent epidemiological data exist relating to itp in adults.
Several other researchers have reported similar results in previous studies, 25. Medical management of itp in pregnancy ash and bcsh guidelines. What is idiopathic thrombocytopenia purpura or itp. Diagnosis and management of thrombotic thrombocytopenic. The magnitude of the maternalfetal risk of itp during pregnancy is. Idiopathic thrombocytopenic purpura itp better health. Idiopathic thrombocytopenic purpura and pregnancy it is generally agreed that, to sustain a diagnosis of idiopathic thrombocytopenic purpura, the following criteria must be fulfilled. Idiopathic thrombocytopenic purpura commonly affects women of childbearing. A practice guideline developed by explicit methods for the american society of hematology by james n. Rare disorders like hemolytic uremic syndrome and thrombotic thrombocytopenic purpura ttp, which uses a lot of platelets to make small blood clots throughout your body. We report our experience of idiopathic thrombocytopenic purpura during pregnancy during the last.
Apr 30, 2019 immune thrombocytopenia itp is a disorder that can lead to easy or excessive bruising and bleeding. The first line of treatment in itp is corticosteroid therapy 1, 57, 12, however patients on steroids have an increased risk of. This condition is now more commonly referred to as immune thrombocytopenia itp. The bleeding results from unusually low levels of platelets the cells that help blood clot. Major diagnostic concerns in an adult with suspected itp are. In 1994, the american society of hematology ash established a panel to produce explicitly developed practice guidelines for the diagnosis. The need for close monitoring of fetal welfare in late pregnancy and the advantages of caesarean section are emphasized. Symptoms may include bruising, nosebleed or bleeding in the mouth, bleeding into the skin, and abnormally heavy menstruation. It is characterised by low platelet count and predominantly mucocutaneous bleeding. Pdf idiopathic thrombocytopenic purpura and anaemia in a. Obstetrics idiopathic thrombocytopenic purpura in pregnancy robert a. Immune thrombocytopenic purpura in pregnancy request pdf. Idiopathic thrombocytopenic purpura is a very rare disease, especially during pregnancy.
Thrombocytopenia, defined as a platelet count 26 000 women suggest that its prevalence at the end of pregnancy is between 6. In patients who develop severe itp refractory to steroids and ivig, and who are beyond. This is because platelets are being destroyed by the immune system. Mar, 2019 idiopathic thrombocytopenic purpura is a condition causing a persistently low number of platelets in the blood, due to an unknown cause. In autoimmune disorders your body makes proteins called antibodies which damage another part of your body.
Diagnosis of exclusionassociated with hiv, hcv, sle, cllcbc normal except low platelets. Retrospective case studies of itp in pregnancy indicate that almost. Pdf immune idiopathic thrombocytopenic purpura itp is an uncommon, but important cause of thrombocytopenia in pregnancy. Coagulation failure in pregnancy coagulation platelet. Risk factors for neonatal thrombocytopenia in pregnancy complicated by idiopathic thrombocytopenic purpura. If the exact cause of this condition isnt known, its called idiopathic thrombocytopenic purpura. There are many forms to monitor and treat these patients.
Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy idiopathic thrombocytopenic purpura itp is an autoimmune disorder characterized by persistent thrombocytopenia peripheral blood platelet count in addition, a further 4 cases of idiopathic thrombocytopenic purpura associated with pregnancy are reported. Out of 16 patients with idiopathic thrombocytopenic purpura, eight were already diagnosed while the other eight were diagnosed during pregnancy. Maternity guidelines thrombocytopenia in pregnancy gl927. Keywords hellp syndrome immune idiopathic thrombocytopenic purpura preeclampsia thrombotic thrombocytopenic purpura. Pdf immune thrombocytopenic purpura itp and pregnancy a. Hamed professor of hematology, faculty of medicine, alexandria university, egypt introduction ttp is a rare lifethreatening disease, characterized by maha, thrombocytopenia, fever, renal involvement and neurologic manifestations 1.
Suggestions will be made later in this course on how the patient should be treated, including appropriate diagnostic testing, pharmacological treatment, and supportive care. J blood disord symptoms treat secondary to the thrombocytopenia purpura, ecchymosis, menorrhagia, epistaxis, hematuria, and gastrointestinal hemorrhage are also common 4. Maternal and perinatal outcome in idiopathic thrombocytopenic purpura itp with pregnancy. New criteria to diagnose preeclampsia, judicious reliance on measurement of adamts to make management decisions in suspected thrombotic thrombocytopenic purpura, new evidence supporting the efficacy and safety of anticomplement therapy for atypical hemolytic uremic syndrome during pregnancy, and implications of thrombotic microangiopathies. Immune thrombocytopenia purpura itp, also known as idiopathic thrombocytopenic purpura, is a type of thrombocytopenic purpura defined as an isolated low platelet count with a normal bone marrow in the absence of other causes of low platelets. It is one of the more common causes of thrombocytopenia in otherwise asymptomatic adults. Mary mary is a 45yearold female with no significant medical history. The bodys immune system mistakenly attacks and destroys platelets. Here, we present a case of a pregnant woman, with idiopathic thrombocytopenic purpura, who was submitted to treatment only when the platelet count was below 10 000. The aim of the present study was to report the perinatal outcome in pregnant women with itp. Immune thrombocytopenic purpura itp in pregnancy oxford. Jun 06, 2016 idiopathic thrombocytopenic purpura itp is a bleeding disorder characterized by too few platelets in the blood.
Though fetal intracranial hemorrhage is a rare complication of itp in pregnancy, invasive studies designed to determine the fetal platelet count before delivery are associated with greater risk than that of fetal intracranial hemorrhage, and therefore are discouraged. Itp is a disorder that can lead to easy or excessive bruising and bleeding. Platelet disorder support association for people with itp. The impact of idiopathic thrombocytopenic purpura in. Thrombocytopenia during pregnancy is associated with many diseases, of which idiopathic thrombocytopenic purpura is the most common in the first trimester. Platelets are cell fragments that are found in the blood and normally help the blood to clot. Coagulation failure in pregnancy free download as powerpoint presentation. It is a condition in, which there is bruising purpura because there are fewer platelets in the blood than usual thrombocytopenia and it is not known what causes it idiopathic. Twenty one pregnant women with itp admitted in a teaching hospital in tehran, from october 2008. Dec 14, 2019 immune thrombocytopenia itp, previously known as idiopathic thrombocytopenic purpura, is defined as isolated thrombocytopenia with normal bone marrow and in the absence of other causes of thrombocytopenia. Aug 01, 2018 idiopathic thrombocytopenic purpura itp, also known as primary immune thrombocytopenic purpura and autoimmune thrombocytopenic purpura, is defined as isolated thrombocytopenia with normal bone marrow and in the absence of other causes of thrombocytopenia. Itp has two distinct clinical syndromes, manifesting as an acute condition in children and a chronic condition in adults. Inherited thrombotic thrombocytopenic purpura mimicking.
Idiopathic thrombocytopenic purpura is an immune disorder in which the blood doesnt clot normally. Mar 26, 2018 immune thrombocytopenic purpura itp is an autoimmune disorder. Thrombocytopenia and idiopathic thrombocytopenic purpura webmd. Idiopathic thrombocytopenic purpura and anaemia in a pregnant mare. This type is caused by autoimmune diseases, such as lupus and rheumatoid arthritis. In pregnant women who have failed glucocorticoid and. Guidelines for the investigation and management of idiopathic. Idiopathic thrombocytopenia purpura itp smarty pance. Idiopathic thrombocytopenic purpura itp is a rare autoimmune disorder that causes you to have low platelet levels. Guideline for the management of thrombocytopenia in pregnancy. Idiopathic thrombocytopenic purpura in pregnancy sciencedirect. Diagnosis and management of thrombotic thrombocytopenic purpura. Idiopathic thrombocytopenia purpura is a blood disorder affecting the platelets.
Formerly known as idiopathic thrombocytopenic purpura, itp can cause purple bruises, as well as tiny reddishpurple dots that look like a rash. Autoimmune reaction to platelets usually after a viral illness itp is insidious and chronic. To examine pregnancy and birth outcomes among women with idiopathic thrombocytopenic purpura itp or chronic itp citp diagnosed before or during pregnancy. Thrombocytopenia in pregnancy obstetrics and gynecology. Itp may develop even during the third trimester, and platelet counts 5080. Immune thrombocytopenic purpura itp is a condition which causes the number of platelets in your blood to be reduced. Diagnosis and management of thrombotic thrombocytopenic purpura nahla a. Idiopathic thrombocytopenic purpura genetic and rare. Idiopathic thrombocytopenic purpura during pregnancy bmj. Management of immune thrombocytopenic purpura in adults. The following organizations have issued guidelines for the management of immune thrombocytopenia itp during pregnancy. Autoimmune thrombocytopenic purpura idiopathic thrombocytopenic purpura immunoglobulin g igg diagnosis. Idiopathic thrombocytopenic purpura itp is a common hematologic disorder caused by immunemediated thrombocytopenia. Aug 19, 2019 idiopathic thrombocytopenic purpura in pregnancy.
Thrombotic thrombocytopenic purpura ttp is a blood disorder that results in blood clots forming in small blood vessels throughout the body. Immune thrombocytopenia itp, also called idiopathic thrombocytopenic purpura, immune thrombocytopenic purpura is an acquired thrombocytopenia caused by autoantibodies against platelet antigens. Thirteen mothers with itp gave birth to twelve babies and two fetuses died. Immune thrombocytopenia itp symptoms and causes mayo clinic. Diopathic thrombocytopenic purpura itp, also known as primary immune thrombocytopenic purpura is a hematologic disorder for which appropriate diagnostic and treatment strategies are uncertain.
Primary immune thrombocytopenic purpura itp, also known as idiopathic thrombocytopenic purpura, is an immunemediated disorder in which platelets are opsonized by autoreactive antibodies and prematurely destroyed by the reticuloendothelial system. Pregnancy outcomes in women with idiopathic thrombocytopenic. Management of itp in pregnancy can be a complex and challenging task, and may be complicated by fetalneonatal thrombocytopenia. Once the antibodies have attached to platelets, the platelets do not work so well. Children supportive care ivig for refractory cases. In people with itp, the body produces antibodies that attack and destroy the platelets. We observed pregnant women of 70 females with idiopathic thrombocytopenic purpura itp from january 1992 through september 2002. Thrombocytopenia, defined as a platelet count pregnancy. A linkage of mothers and babies within a large us health insurance database that combines enrollment data, pharmacy claims, and medical claims was carried out to identify pregnancies in women with itp or. Guidelines published by organizations or institutions such as the national. Pregnancy in patients with idiopathic thrombocytopenic purpura. Guidelines for the investigation and management of.